Animal models for parkinson's disease pdf

Animal models of Parkinson's disease - ScienceDirect

Available from: Javier Blesa, Ines Trigo‐Damas, Ana Quiroga‐Varela and Natalia Lopez‐Gonzalez del Rey (August 24th 2016).

PDF New Animal Models of Parkinson's Disease

The identification of PD-related genes has led to the development of genetic PD models as an alternative to the classical toxin-based ones, but does the dopaminergic neuronal loss in actual animal models adequately recapitulate that of the human disease?

<b>Animal</b> <b>models</b> of Parkinson's <b>disease</b> - ScienceDirect

Animal Models of Parkinson's Disease - Hindawi

Javier Blesa, Ines Trigo‐Damas, Ana Quiroga‐Varela and Natalia Lopez‐Gonzalez del Rey (August 24th 2016).

Classic and New Animal Models of Parkinson's Disease

A hallmark feature of PD is the degeneration of the dopamine (DA) neurons in the substantia nigra pars compacta (SNc) and the consequent striatal DA deficiency. Despite tremendous growth in recent years in our knowledge of the molecular basis of PD and the molecular pathways of cell death, important questions remain, such as: (1) why are SNc cells especially vulnerable; (2) which mechanisms underlie progressive SNc cell loss; and (3) what do Lewy bodies or α-synuclein reveal about disease progression. doi: 10.1523/JNEUROSCI.5809-11.2012 Pubmed Abstract | Pubmed Full Text | Cross Ref Full Text | Google Scholar Gandhi, S., Wood-Kaczmar, A., Yao, Z., Plun-Favreau, H., Deas, E., Klupsch, K.,et al. PINK1-associated Parkinson’s disease is caused by neuronal vulnerability to calcium-induced cell death.


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